Department of Chemistry
Indian Institute of Technology Delhi

Calcium in Organic Synthesis

Prof. Vincent Gandon

Université Paris-Sud, France

Date: August 29th 2019 (Thursday)
Time: 4:00 PM
Venue: Committee Room (MS710), Chemistry Department, 6th Floor

Abstract: Over the past 5 years, our group has developed a variety of calcium-catalyzed transformations that lead to useful building blocks in a straightforward manner. In particular, oxygen- and nitrogen-based heterocycles can be rapidly constructed by condensation reactions relying on  C(sp3)-O bond activation, or cycloisomerization reactions triggered by C-C π-bond activation. These - and π-activations can be achieved in the presence of a catalytic amount of the calcium ion [Ca(NTf2)]+, which confers high levels of chemo-, regio-, and stereoselectivity. This presentation will summarize our findings in the development of novel synthetic methodologies based on calcium catalysis.[1]

  1. C. Qi, F. Hasenmaile, V. Gandon, D. Leboeuf, ACS Catal. 2018, 8, 1734.
  2. Qi, C.; Gandon, V.; Lebœuf, D. Angew. Chem. Int. Ed. 2018, 57, 14245.

    About the speaker: Vincent Gandonreceived his Ph.D. in 2002 from the University of Reims Champagne Ardenne(group of Prof. Jan Szymoniak). After a postdoctoral stay at the University of California, Riverside, in the group of Prof. Guy Bertrand, he joined the faculty of the Pierre et Marie Curie University in Paris in 2003, as Assistant Professor, in the laboratory of Prof. Max Malacria. In 2009, he was appointed full Professor at the Paris-Sud University with a research excellence chair. He is co-author of 164 publicationsIn 2013, he received the Jean Normant award of the Organic Chemistry Division of the French Chemical Society. He was elected junior distinguished member of the French Chemical Society in 2015. In 2018, he received the Jean-Marie Lehnprize of the Organic Chemistry Division of the French Chemical Society.
    Main research interest: The Gandon group focuseson the development of Lewis acid catalyzed cyclization reactions. Simple acyclic precursors are transformed into complex polycyclic compounds in a stereoselective fashionto grant an easy access to advanced building blocks towards bioactive products. Innovative catalytic systems aredesigned for that purpose. The catalytic activity and the peculiar selectivities observed arerationalized by means of DFT computations.

    All are cordially invited to attend.
    Convener (Seminar)