Department of Chemistry
Indian Institute of Technology Delhi

Essential Role of Protein Kinases in Regulation of Molecular Pathways in Malaria Parasite Plasmodium Falciparum

Dr. Mahmood M Alam

The University of Glasgow

Date: September 23rd 2019 (Monday)
Time: 4 PM
Venue: Committee Room (MS710), Chemistry Department, 6th Floor

Abstract: Despite the identification of at least half of the kinome as essential for survival of the malaria parasite, the molecular pathways that are regulated by protein kinases and the potential of targeting protein kinases for development of new anti-malarial drugs remain largely unexplored. In this direction, I have applied the techniques of phospho-proteomics, chemical-genetics and conditional gene deletion to identify the essential functions of cyclic nucleotide dependent protein kinases in regulation of host-pathogen interactions between the malaria parasite and the host erythrocyte. Further, towards validating protein kinases as a drug target, I have identified a parasite kinase namely cyclin-dependent like protein kinase-3 (PfCLK3) as a genuine candidate for development of new anti-malarial drugs. In my presentation, I will be discussing the role of protein kinase A (PfPKA) and protein kinase G (PfPKG) in regulation of Plasmodium falciparum invasion of host erythrocyte and the recent study on identification of a specific inhibitor of PfCLK3 to investigate the essentiality of PfCLK3 at multiple stages of parasite life cycle. I will be presenting evidence to show that targeting of protein kinases can be a step forward towards achieving the aim of malaria elimination.

All are cordially invited to attend.
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