Date: December 17th 2019 (Tuesday)
Time: 11:00 AM
Venue: Committee Room (MS710), Department of Chemistry, IIT Delhi
Abstract: Staphylococcus aureus is an important bacterial pathogen that can cause severe infections to humans. Cell wall reactive antibiotics, such as beta-lactams, is one of the gold standards for treatment of bacterial infections due to their efficacy and safety of use in clinics. Resistance to beta-lactams makes it often very difficult for it to be used for therapy. We have recently identified that an uncanonical penicillin binding protein, PBP4, the second messenger Cyclic-Di-AMP (CDA) and a Serine-Threonine Kinase (STK) signaling system play a crucial role in beta-lactam resistance in S. aureus that was under appreciated before. Currently my lab is focused to determine the mechanisms through which PBP4, CDA and STK mediate resistance against beta-lactam drugs with the goal of finding better or newer ways of treating the bacterial pathogen.
For more details, please visit: https://imet.usmd.edu/chatterjee