Department of Chemistry
Indian Institute of Technology Delhi

Copper Catalyzed Asymmetric Conjugate Addition to Sensitive Michael Acceptors

Prof. Gremaud Ludovic

School of Engineering and Architecture Fribourg, Switzerland

Date: November 29th 2019 (Friday)
Time: 3:00 PM
Venue: Committee Room (MS710), Chemistry Department, 6th Floor

Abstract: Enantioselective Cu-catalyzed conjugate addition of organometallic reagents to sensitive Michael acceptors and their application to the synthesis of relevant target molecules. This is one of the most important methodologies to form a C–C bond in an enantioselective manner. A wide range of α,β-unsaturated aldehydes and β,γ-unsaturated-α-ketoesters has been successfully used. Reactivity, regio- and enantio-selectivities were strongly dependent on the reaction conditions, therefore moderate to very good results were obtained. Furthermore, γ-substituted-α-ketoesters were used as chiral building blocks for further derivatization with complete retention of the chiral information to obtain key compounds.

About the Speaker

All are cordially invited to attend.
Convener (Seminar)