Department of Chemistry
Indian Institute of Technology Delhi

Biological effects of metallic and bimetallic nanoparticles (silver,gold, platinum metals)

Dr. Matthias Epple
University of Duisburg Essen, Institute of Inorganic Chemistry, 45141 Essen, Germany. Email:

Date: March 26th 2018 (Monday)
Time: 3:30 PM
Venue: Committee Room, Chemistry Department, 6th Floor

Metallic nanoparticles are used in nanomedicine since decades, due to their easy preparation and the possibility for selective surface functionalization. In particular, noble metals have been used as they are typically biologically inert in the body, i.e. they do not dissolve and they do not have harmful side-effects. Silver is an exception because its antibacterial effect is due to the release of silver ions. Alloyed nanoparticles give a combination of the properties of the single metals, e.g. antibacterial effects and surface plasmon resonance (SPR). Synthetic concepts for preparation and characterization of such nanoparticles are presented. Bimetallic nanoparticles with different elemental distribution (core-shell or alloy or graded alloy) were analyzed by high-resolution transmission electron microscopy, including elemental distribution inside a nanoparticle. Besides such larger nanoparticles (size about 10 nm), recent developments on ultrasmall gold nanoparticles are shown. They are smaller than common proteins, and they can be selectively functionalized to address specific surface epitopes of proteins.

All are cordially invited to attend.
Convener (Seminars)