Indian Institute of Technology Delhi
Biological effects of metallic and bimetallic nanoparticles (silver,gold, platinum metals)
Dr. Matthias Epple
University of Duisburg Essen, Institute of Inorganic Chemistry, 45141 Essen, Germany. Email: firstname.lastname@example.org
Date: March 26th 2018 (Monday)
Time: 3:30 PM
Venue: Committee Room, Chemistry Department, 6th Floor
Metallic nanoparticles are used in nanomedicine since decades, due to
their easy preparation and the possibility for selective surface
functionalization. In particular, noble metals have been used as they are
typically biologically inert in the body, i.e. they do not dissolve and
they do not have harmful side-effects.
Silver is an exception because its antibacterial effect is due to the
release of silver ions. Alloyed nanoparticles give a combination of the
properties of the single metals, e.g. antibacterial effects and surface
plasmon resonance (SPR). Synthetic concepts for preparation and
characterization of such nanoparticles are presented. Bimetallic
nanoparticles with different elemental distribution (core-shell or alloy
or graded alloy) were analyzed by high-resolution transmission electron
microscopy, including elemental distribution inside a nanoparticle.
Besides such larger nanoparticles (size about 10 nm), recent developments
on ultrasmall gold nanoparticles are shown. They are smaller than common
proteins, and they can be selectively functionalized to address specific
surface epitopes of proteins.
All are cordially invited to attend.