Seminar


Department of Chemistry
Indian Institute of Technology Delhi

Oxidative Functionalization of C-H Bond Using Molecular Oxygen

Dr. Joyram Guin
Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata 700032, INDIA, email: ocjg@iacs.res.in

Date: April 24th 2018 (Tuesday)
Time: 04:00 PM
Venue: Committee Room, Chemistry Department, 6th Floor

Oxidative functionalization of ubiquitous and inert C-H bonds receives significant interest in organic synthesis. In view of the growing demand toward green and sustainable chemical process, molecular oxygen (O2) is recognized as an ideal oxidant for the oxidative organic transformations. In this seminar, the concept of generating valuable alkyl/acyl radicals employing aerobic oxidation of aldehyde will be introduced. It will be shown that O2 is capable of promoting direct acylation/alkylation of unactivated C-H bond via radical addition1 or addition/cyclization cascade reactions.2 Furthermore, dioxygen activation employing auto-oxidation of aldehyde and its utilization in Pd-catalyzed direct aerobic C-H hydroxylation will be presented during the lecture.3

    References:
  1. Paul S., Guin J. Chem. Eur. J. 2015, 21, 17618.
  2. Biswas P., Paul S., Guin J. Angew Chem., Int. Ed. 2016, 55, 7756.
  3. (a) Das P., Saha D., Saha D., Guin, J. ACS Catal. 2016, 6, 6050; (b) Das P., Guin J. ChemCatChem. 2018 (accepted).


All are cordially invited to attend.
Convener (Seminars)