Indian Institute of Technology Delhi
Oxidative Functionalization of C-H Bond Using Molecular Oxygen
Dr. Joyram Guin
Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata 700032, INDIA, email: email@example.com
Date: April 24th 2018 (Tuesday)
Time: 04:00 PM
Venue: Committee Room, Chemistry Department, 6th Floor
Oxidative functionalization of ubiquitous and inert C-H bonds receives significant interest
in organic synthesis. In view of the growing demand toward green and sustainable
chemical process, molecular oxygen (O2) is recognized as an ideal oxidant for the
oxidative organic transformations. In this seminar, the concept of generating valuable
alkyl/acyl radicals employing aerobic oxidation of aldehyde will be introduced. It will be
shown that O2 is capable of promoting direct acylation/alkylation of unactivated C-H bond
via radical addition1 or addition/cyclization cascade reactions.2 Furthermore, dioxygen
activation employing auto-oxidation of aldehyde and its utilization in Pd-catalyzed direct
aerobic C-H hydroxylation will be presented during the lecture.3
- Paul S., Guin J. Chem. Eur. J. 2015, 21, 17618.
- Biswas P., Paul S., Guin J. Angew Chem., Int. Ed. 2016, 55, 7756.
- (a) Das P., Saha D., Saha D., Guin, J. ACS Catal. 2016, 6, 6050; (b) Das P., Guin J.
ChemCatChem. 2018 (accepted).
All are cordially invited to attend.