Indian Institute of Technology Delhi
Tryst with Endosomes: A Novel GPCR Activation Paradigm and Therapeutic Opportunities
Dr. Prasenjit Mitra
Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India
Date: October 31st 2017 (Tuesday)
Time: 4 PM
Venue: Committee Room, Chemistry Department, 6th Floor
G protein coupled receptors (GPCRs) after activation associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling following which the receptor-ligand complex undergoes desensitization, internalization and is either recycled back to the plasma membrane or degraded in lysosomes. Contrary to this canonical pathway, our laboratory has discovered a novel molecular mechanism in which a Class B GPCR, Glucagon –Like Peptide 1 Receptor (GLP-1R), supports sustained cyclic AMP generation following activation and internalization at endosomes. We have set up a screening platform that could identify small molecules modulating GLP-1R mediated endosomal cyclic AMP generation and contributes to Glucose Stimulated Insulin Secretion and pancreatic beta cell survival.
All are cordially invited to attend.