Indian Institute of Technology Delhi
Highly Efficient Catalytic Asymmetric Hydrogenations
Dr. Qi-Lin Zhou
College of Chemistry, Nankai University
Tianjin 300071, China.
Date: January 16th 2018 (Tuesday)
Time: 4 PM
Venue: Committee Room, Chemistry Department, 6th Floor
Transition-metal-catalyzed asymmetric hydrogenation is one of the most important asymmetric reactions, which received continuing attention from both academia and industry. Many chiral catalysts have been synthesized and applied in asymmetric hydrogenation reaction over the past few decades. However, for the most of reported chiral catalysts, the enantioselectivity is substrate-dependent, and the efficiency is far from the requirements for industrial productions. Therefore, the search for efficient chiral catalysts in terms of high enantioselectivity and high activity has long been an important goal in the area of asymmetric hydrogenation. We developed a new class of chiral ligands with a spirobiindane framework, including monodentate phosphines, diphosphines, phosphine-oxazolines and aminophosphines. The chiral spiro ligands showed high efficiency and high enantioselectivity in a number of transition-metal-catalyzed asymmetric hydrogenation reactions. The synthesis, structure and reactivity of chiral spiro catalysts in asymmetric hydrogenation, as well as the reaction mechanism were be discussed in the presentation.
All are cordially invited to attend.