Date: January 13th 2020 (Monday)
Time: 3:30 PM
Venue: Committee Room (MS710), Department of Chemistry, IIT Delhi
Abstract: Neglected parasitic diseases affect millions of people in developing countries. Some of these conditions are caused by protozoan parasites, among which are malaria, leishmaniasis and trypanosomiasis. The arsenal of existing drugs for the treatment of these diseases is inadequate in terms of efficiency, toxicity and development of resistance.
Our laboratory has been focused on establishing a program to advance on the development of drugs for the treatment NTDs. To this purpose, we have set a strategy to find new chemical entities (NCE), subsequently working on the development of new leads. The search for NCE begun alternatively from the design of inhibitors of previously validated therapeutic targets or from the phenotypic assay of collections of synthetic compounds natural products derivatives. The compounds have been tested against the etiological agents of malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, selecting specific hits for each pathology or as broad-spectrum agent.
Our work program has been expanded to study the action mechanism, to validate the biological targets and introducing computational chemistry tools to evaluate the ADME-Tox profiles. As a result of those efforts, we have been able to find derivatives of aliphatic diamines, sterols, amino acids and isoprenylated compounds, among others, which are positioned as excellent candidates for the development of new drugs.
In the seminar different examples of the strategy, the difficulties encountered in its implementation will be addressed pointing out the current development stage of the leading compounds