Lewis base complexes of borane unlocked the huge potential of reactive and pyrophoric diborane gas. Indeed, borane-THF or borane-SMe2 has become common laboratory reagents. In comparison, due to the strong boron-nitrogen complex and their lack of reactivity, borane-amines are used for very selective organic chemistry applications. However, recently there has been an increased interest in amine-boranes due to their air- and moisture-stability. They have found several applications as hydrogen storage materials, green hypergolic bipropellants, and precursors to polyaminoboranes, etc. Furthermore, they have been used as reagents for hydroboration, reduction, hydrogenation, reductive amination, borylation, and B-H insertion.
Despite these advances, amine-boranes are very expensive and amine-boranes bearing functional groups are scarce, presumably due to their incompatibility to borane. Current approaches to amine-boranes from amines, such as exchange with borane-Lewis base complexes or metathesis of alkylammonium salts with metal borohydrides, have several drawbacks. New procedures for the preparation of amine-boranes, including previously inaccessible borane-intolerant amine-boranes and the mechanism of their formationwill be discussed.Also, novel applications of amine-boranes, including open-to-air hydroboration of alkenes and alkynes will be presented.
About the speaker:
Professor P. V. Ramachandran received his Ph. D. from the Indian Institute of Technology, Kanpur under the tutelage of Professor S. Ranganathan. He then joined the laboratories of Professor Herbert C. Brown at Purdue University as a post-doctoral research associate and soon became Professor Brown's Research Assistant. Later he, joined the faculty of Purdue Chemistry Department as an Assistant Professor and rose through the ranks to become a Professor. He also serves as the Director of the Herbert C. Brown Center for Borane Research at Purdue.
For his contributions to boron science, he received the Boron in the Americas Award in 2006. He served as the Chair of the Fluorine Division of the American Chemical Society. He is a Fellow of the Royal Society of Chemistry, was selected as a Fellow of the American Chemical Society in 2012, andwas awarded the Vikram Sarabhai Chair of the Indian National Science Academy for 2014-2015.
Prof. Ramachandran's research focuses on the application of organoborane and fluoroorganic chemistry. His lab develops novel methods and reagents to facilitate the synthesis of a variety of complex molecular targets, particularly for the treatment of cancer, inflammation, and central nervous system disorders. They also focus on the mechanistic aspects of such methodologies. He has published over 225 papers and has edited two books.
All are cordially invited to attend.