Carboxylic acids are needed as bulk chemicals in large amounts in various fields including fine chemicals, polymers and many commercial products. The global production of aryl carboxylic acids was estimated as 480 kilotons in 2014 and is likely to exceed 620 kilotons by 2023. Terephthalic acid (TPA), the monomer for the polyester PET, used extensively for the manufacture of mineral water and beverage bottles has a worldwide demand of 12.6×106 tons. 2, 5- Furandicarboxylic acid (FDCA) has been identified by the US Department of Energy as one of the twelve priority chemicals for establishing the “green” chemistry industry of the future. Susanta Hazra and Mayukh Deb working with Prof. Anil J. Elias of the chemistry department have developed a novel transition metal free methodology to oxidize wide range of alcohols and aldehydes to carboxylic acids including terephthalic acid using water as the solvent, iodine/NaOH as catalyst and a source of oxygen. They have shown that their method can produce FDCA in good yields even in large scale reactions. The present work is published in Green Chemistry; 2017, DOI: 10.1039/C7GC02802D. The research paper can be downloaded from the journal website. Link For further details and more on similar research see the webpage. The research paper can be downloaded from the journal website.
The synthesis of polycrystalline Cd3As2, a 3D Dirac Semi Metal (DS) was carried out by Gohil S. Thakur, Zeba Haque and Ashok K. Ganguli at Department of Chemistry, IIT Delhi and the point contact Andreev reflection spectroscopic measurement was done by Dr. Goutam Sheet and his students of IISER Mohali. A 3D DS is a bulk analogue of graphene and has a linear dispersion along all the three momentum directions. These materials have intriguing electronic properties and can be related to other exotic states through quantum phase transitions. Cd3As2 is itself not a superconductor nor the Ag tip used for point contact measurements, but we observesuperconductivity with an onset transition temperatureTc ~ 6 K. This is a unique phenomenon of observing superconductivity at mesoscopic point contacts between pure silver metal (Ag) and Cd3As2. The reason for this unconventional superconductivity is due to the injection of electrons by the Ag tip into the Cd3As2 and creating a superconducting region at the mesoscopic contact. Thus our discovery of superconductivity in a 3D Dirac semimetal provides an ideal case to study topological systems. The present work is published in Nature Materials, 2016, 15, 32-37. For further details and more on similar research see the webpage. The research paper can be downloaded from the journal website.
Extremophiles are exotic microorganisms able to grow and thrive under extreme environmental conditions such as extreme temperature, pH, salt and solvents etc. Halophiles refer to the organisms having unusual life existence in saline/ hypersaline environments.
“Haloenzymes”, the proteins from such halophilic origin, are endowed with unique structural features and catalytic power to sustain the metabolic and physiological processes under high salt conditions. One such halophile Geomicrobium sp. EMB2 is isolated by us. Molecular characterization of its novel protease is presented here. J. Microbiol. Biotechnol., 2011, 21, 129–135.
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Crowding affects a number of protein characteristics, including its structure, stability, function, and activity. Majority of studies involving macromolecular crowding have mainly focused on the global changes of the protein structure (e.g. secondary or tertiary structure changes using circular dichroism spectroscopy). In this work we have used the fluorescence modulation of an intrinsic fluorophore (Trp) of two serum albumins (BSA and HSA) to focus on the extensive local perturbations of protein structure in presence of the crowding agents. These results have significant structural implications with regards to the functional aspects of proteins in the physiological environment.
For further details and more on similar research see the webpage. The research paper can be downloaded from the journal website. Ref: Journal of Physical Chemistry Letters, 2013, 4, 2610-2617, DOI: 10.1021/jz401179z
The Suzuki-Miyaura cross-coupling of aryl halides with organoboronic acids is an important tool for synthetic organic chemistry. A range of palladium complexes with different ligands can been used to catalyse this interesting reaction and Ajai Kumar Singh and co-workers have synthesised four new ligands (selenated Schiff bases) to investigate the influence alkyl chain lengths have on the [Pd(L-H)Cl] complexes and their catalytic efficiency. Their remarkable results indicate there is a correlation between ligand alkyl chain length and catalytic efficiency, however, as their Dalton Transactions HOT Article details, the Pd(II) complexes are pre-catalysts which generate in situ real catalytic species of approx. 3 nm Pd(0) nanoparticles, protected by organoselenium species.
For further details and more on similar research see the webpage. The research paper can be downloaded from the journal website. Ref: Dom the journal website. Ref: Dalton Trans., 2012, Advance Article, DOI: 10.1039/C1DT11695A
Core-Shell nanostructures can be designed by low temperature methods . The shell can alter the reactivity of the surface and enhance the stability and dispersibility of the colloidal core. It also helps in passivation of the core .By suitable combination of core and shell modification of optical and magnetic properties of the nanostructures are possible . One such example is : Silica encapsulated magnetic nanoparticles for enhanced stability and ability to bind with biomolecules. For further details and more on similar research see the webpage. The research paper can be downloaded from the journal website.
The differences in (i) charge, (ii) stability of helix and (iii) propensity of α-helix segment of TGF-β1(A) and TGF-β3 (B) to change to b-sheet after 10 ns MD simulation at 500 K.
TGF-β3 has hydrophobic patch which may be responsible for low solubility.
TGF-β3 has low charge than TGF-β1 under all pH conditions.
One of the α-helix in TGF-β3 is unstable.
This α-helix segment changes to β-sheet after 10 ns MD simulation at 500 K.
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The research paper can be downloaded from the journal website.
Reference: Nayeem S. M., Deep S. (2010), Rationalization of poor solubility of TGF-β3 using MD simulation. Biochemical Biophysical Research communication, 401, 544-547.
Demonstration of dual emission from a single semiconductor hetero-nanostructure comprising of both Type-I and Type-II junctions.
For further details and more on similar research see the webpage. The research paper can be downloaded from the journal website. Ref: ACS Nano, 2013, ASAP, DOI: 10.1021/nn404537s