N G Ramesh




N G Ramesh



Professor


Ph.D. (Prof. K. K. Balasubramanian) IIT Madras,

Postdoctoral fellow:

1. Prof. Alfred Hassner at Bar-Ilan University, Israel.

2. Prof. Binne Zwanenburg at the University of Nijmegen, The Netherlands.

3. JSPS postdoctoral fellow with Prof. Yasuyuki Kita at Osaka University, Japan. Indian Institute of Technology Delhi, 2000-present.




Group Webpage



Research Interests


Our group’s research activities mainly focus on the synthesis of biologically active natural products and their analogues from readily available and cheap carbohydrates as a “chiral pool” through some novel and interesting chemical transformations. Our main aim is to develop a “Diversity Oriented Approach” towards the synthesis of a library of skeletally distinct small and novel molecules with potential biological applications. Glycals (carbohydrate derived enol-ethers), which are perhaps the most versatile monosaccharides, are being extensively exploited by us, as convenient starting materials, to realize our research focus.
Illustrative examples of natural products and their mimics that were synthesized recently and are being pursued currently in our lab include, 1-deoxy-L-gulonojirimycin, DMDP analogues, amino-DMDP analogues, chiral 2,6-diazabicylo[3.2.1]octan-4,8-diol (a chiral conformationally restricted diamine), (‒)-pochonicine stereoisomers, steviamine stereoisomers, conduramines, (+)-anisomycin, bulgecinine, kirkamide etc. Apart from synthesis, we also carry out the inhibition studies of new compounds that were/are being synthesized in our lab. Some of these compounds display inhibition against glycosidases, SOD1 fibril formation etc.


research pic

Selected Publications


  1. V Santhanam, P. Pant, B. Jayaram, N. G. Ramesh, “Design, Synthesis and Glycosidase Inhibition Studies of Novel Triazole Fused Iminocyclitol-δ-lactams”, Org. Biomol. Chem., 2019, DOI: 10.1039/c8ob03084g.
  2. V. K. Harit and N. G.Ramesh, “A Chiron Approach to Diversity-Oriented Synthesis of Aminocyclitols, (−)- Conduramine F-4 and Polyhydroxyaminoazepanes from a Common Precursor”, J. Org. Chem., 2016, 81, 11574–11586.
  3. A. Shandilya, M. Ganesan, F. Parveen, N. G. Ramesh and B.Jayaram, “Molecular basis for the affinity and specificity in the binding of fivemembered iminocyclitols with glycosidases: an experimental and theoretical synergy”, Carbohydr. Res., 2016, 429, 87‒97.
  4. R. V. Salunke and N. G. Ramesh, “A Concise Total Synthesis of the Stereoisomers of (‒)-Pochonicine”, Eur. J. Org. Chem., 2016, 654–657.
  5. V. K. Harit and N. G. Ramesh, “Amino-functionalized iminocyclitols: synthetic glycomimetics of medicinal interest” RSC Advances, 2016, 6, 109528‒109607.
  6. V. Santhanam and N. G. Ramesh, “A Glycal Approach to the Synthesis of Steviamine Analogues”, Eur. J. Org. Chem., 2014, 6992–6999.



Group

      Group Members


  • P. Nagaraj (Ph.D.)
  • Prabaht K. Jaiswal (Ph.D.)
  • M. Ganesan (Ph.D.)
  • Rishi Sharma (Ph.D.)
  • Sandeep Nath Tripathi (Ph. D.)
  • Tanmay Chatterjee (M.Sc.)