Professor

Masters in Biochemistry (1983), Ph.D. IIT Delhi (1989)
United Nation University Fellow (1996-1997), at National Food Research Institute, Tsukuba, Japan. (1996-97), DBT Visiting Assoc, University of Western Illinois/NRRL, USA, 2006, Visiting faculty, University of Blaise Pascal, France, 2014.
Sr. Scientist of Biochemistry, ICAR, New Delhi(1989-2000)
Indian Institute of Technology Delhi, 2000-present
Fellow of International Forum on Industrial Bioprocesses, France, 2013, Fellow of Biotech Research Society of India, 2012, United Nations- Kirin Fellow, 1996-97. United Nations Amway award, 1998
Member, National Academy of Science, India. Honorary member, International Bio-encapsulation Research Group, France. Member, International Society on Extremophiles, Germany
Life Member: Society of Biological Chemists, India

Group Webpage

Research Interests

Extremophiles and extremozymes.

Extremophiles are micro-organisms that inhabit some of earth's most hostile environments and are functional in conditions that were once thought incompatible with life. Our research aims to understand the structural basis of extremophile enzyme stability and catalytic properties. The experimental approaches include microbial screening and isolation, enzymology, molecular biology, proteomics and structure-function studies. The group is also involved in the wide research arena of nanotechnology by working on nanobiocatalysis as well as nanotoxicity. The biomass utilization for production of platform chemicals and enzymes is another engaging aspect where we are actively involved for contributing to circular bio-economy. The expertise of extremophiles, and extremozymes has been optimally manifested for heavy metal and organochlorine bioremediation, thus making a niche in environmental biotechnology/bioremediation.

Selected Publications

1. Ayesha Sadaf and S.K. Khare “Efficacy of ionic liquids on the growth and simultaneous xylanase production by Sporotrichum thermophile: membrane integrity, composition and morphological investigation” RSC Adv. 7, 2017: 21114–21123
2. Amrik Bhattacharya and S.K. Khare “Biodegradation of 4-chlorobiphenyl by using induced cells and cell extract of Burkholderia xenovorans.” Bioremediat J., 2017, doi: 10.1080/10889868.2017.1282940
3. R. Hemamalini and S.K. Khare, “A proteomic approach to understand the role of the outer membrane porins in the organic solvent-tolerance of Pseudomonas aeruginosa PseA”. PLoS ONE 9 (8): e103788, 2014, doi: 10.1371/journal.pone.0103788
4. Rajeshwari Sinha and S.K. Khare, “Effect of organic solvents on structure and activity of moderately halophilic Bacillus sp. EMB9 protease”. Extremophile, 18 (6), 2014:1057-1066

      Group Members

• Dr. Arti Kumari (SERB-Post Doc.)
• Dr. Amrik Bhattacharya (SERB-Post Doc.)
• Dr. Razi Ahmad (SERB-Post Doc.)
• Dr. Rameshwar Tiwari (SERB-Post Doc.)
• Dr. Shivani Chaturvedi (UGC-R.A)
• Dr. Kumar Pranaw (NASF-R.A)
• Ms. R. Hemamalini (Ph.D)
• Ms. Ayesha Sadaf (Ph.D)
• Ms. Jasneet Grewal (Ph.D)
• Ms. Shubhrima Ghosh (Ph.D)
• Ms. Neerja Yadav (Ph.D)
• Ms. Syeda Warisul Fatima (Ph.D)
• Mr. Shahenvaz Alam (Ph.D)
• Mr. Akhilesh Kumar Saini (Ph.D)