Jayaram-research
B Jayaram




Jayaram



Professor


Professor, Department of Chemistry & School of Biological Sciences, IIT Delhi. Coordinator, Supercomputing Facility for Bioinformatics and Computational Biology (SCFBio), IIT Delhi.
Ph.D. from City University of New York (Mentor: Prof. D. L. Beveridge), 1982-1986. Post Doctoral Fellow at Columbia University (PI: Prof. Barry Honig), 1987-88. Senior Research Associate at Wesleyan University (PI: Prof. D. L. Beveridge) 1989-90. Faculty at Indian Institute of Technology Delhi, 1990-present.


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Research Interests


Biomolecular modeling and simulation, Physico-chemical understanding of genomic DNA organization (Chemgenome), protein tertiary structure prediction via chemistry and informatics based methods (Bhageerath) and protein/DNA targeted computer aided drug discovery (Sanjeevini).


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Selected Publications


  1. B. Jayaram, and T. Jain, “The role of water in protein-DNA recognition”, Annu. Rev. Biophys. Biomol. Struct. 2004, 33, 343-361.
  2. B. Jayaram, K. Bhushan, S. Shenoy, P. Narang, S. Bose, P. Agrawal, D. Sahu, V. Pandey, “Bhageerath: an energy based web-enabled computer software suite for limiting the search space of tertiary structures of small globular proteins”, Nucleic Acids Res., 2006, 34, 6195-6204.
  3. S. Shaikh, B. Jayaram, “A swift all atom energy based computational protocol to predict DNA-Drug binding affinity and Tm”, J. Med. Chem., 2007, 50, 2240-2244.
  4. G. Khandelwal and B. Jayaram, “DNA-water interactions distinguish messenger RNA genes from transfer RNA genes”, J. Am. Chem. Soc., 2012, 134, 8814–8816; DOI: 10.1021/ja3020956.





Group

      Group Members


  • Shashank Shekhar
  • Vandana Shekhar
  • Abhilash Jayaraj
  • Ashutosh Shandilya
  • Anjali Soni
  • Rahul Kaushik
  • Ankita Singh
  • Debarati DasGupta
  • Ruchika Bhat
  • Pradeep Pant
  • Amita Pathak
  • Akhilesh Mishra
  • Manpreet Singh