Tanmay Dutta

Tanmay Dutta

Assistant Professor

Born: 1979, Kashipur, Digha, West Bengal
Ph. D. (Dr. Sanjay Ghosh) Calcutta University, 2008
Postdoctoral Associate (Prof. Murray P. Deutscher) University of Miami School of Medicine, FL, USA, Nov 07- Oct 12
Senior Research Associate (Prof. Murray P. Deutscher) University of Miami School of Medicine, FL, USA, Nov 12-July 14
Assistant Professor: Indian Institute of Technology Delhi, Aug 14-Present

Group Webpage

Research Interests

Regulation by Small RNAs in Bacteria

The discovery and characterization of small regulatory RNAs (sRNA) ranging in length from 50-500 nucleotides in bacteria like Escherichia coli, has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other and how they function to regulate different physiological processes are active areas of our research.

Transfer-RNA Metabolism: Role of tRNA-Derived RNA Fragments In Vivo Transfer-RNA metabolism is an important incident for cells' viability. Functional tRNAs are synthesized prior to protein synthesis, however, tRNAs undergo degradation under stress or some unusual conditions. Recent investigations reveal that mutations in the tRNA genes results in a large number of human diseases. Therefore, studies on tRNA metabolism will help understand the reasons behind the generations of defective tRNAs. Recently a new class of microRNA has been identified as tRNA-derived small RNA fragments (tRFs) which are generated under stress or diseased conditions. All these small tRFs appears to be required for different cellular functions. Identification of these tRNA-derived small RNAs, understanding the mechanism and regulation of tRFs generation under stress condition and to investigate the function of those tRFs in cellular process are principal objectives of our research.

    Selected Publications

  1. Tanmay Dutta, Arun Malhotra and Murray P. Deutscher (2013) How a CCA Sequence Protects Mature tRNAs and tRNA Precursors from Action of the Processing Enzyme RNase BN/RNase Z. J. Biol. Chem. 288: 30636-30644.
  2. Tanmay Dutta, Arun Malhotra and Murray P. Deutscher (2012) Exoribonuclease and endoribonuclease activities of RNase BN/RNase Z Both function in vivo. J. Biol. Chem. 287(42): 35747-55.
  3. Tanmay Dutta and Murray P. Deutscher (2010) Mode of action of RNase BN/RNase Z on tRNA precursors. RNase BN does not remove the CCA sequence from tRNA. J. Biol. Chem. 285(30): 22874-81.
  4. Tanmay Dutta and Murray P. Deutscher (2009) Catalytic properties of RNase BN/RNase Z from Escherichia coli. RNase BN is both exo- and endoribonuclease. J. Biol. Chem. 284:15425-15431.

      Group Members

    Ph.D. Students
  • Amit Kumar Gupta
  • Shubhangi Srivastava
  • Laxmi Arora
  • Lokesh Kumar Yadav