Department of Chemistry

Pramit CHOWDHURY
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Office

Department of Chemistry
MS-725
Multi-storey building
6th Floor
IIT Delhi
Hauz Khas, New Delhi 110016
Tel: +91 11 2659 1521
Fax: +91 11 2658 1102



Laboratory

Department of Chemistry
MS-733
Multi-storey building
6th Floor
IIT Delhi
Tel: +91 11 2659 6536
Fax: +91 11 2658 1102



ASSOCIATE PROFESSOR

Born Kolkata, West Bengal. Ph. D. (Prof. J. W. Petrich), Iowa State University, USA, 1999-2004. Post Doctoral Fellow (Dr. Feng Gai), University of Pennsylvania, USA, (Sep-2004 to January-2009). Joined Indian Institute of Technology Delhi in January 2009

E-mail: pramitc

Group Webpage
Research Interests

Protein folding and aggregation. Our main focus is to use single molecule confocal microscopy techniques like fluorescence resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS) to monitor protein dynamics. In particular, we want to lay special emphasis on how macromolecular crowding and confinement influence the folding and aggregation of proteins.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    



(a) Confinement (b) Macromolecular crowding. The unfolded protein is shown in red while the blue sphere represents its native form. The dark spheres in (b) are the inert macromolecular crowders. (Figure adapted from Zhou, Annual Reviews of Biophysics, 2008)

Selected Publications

1. Mukherjee, S., Chowdhury P. and Gai, F. Effect of dehydration on the aggregation kinetics of two amyloid peptides. J. Phys. Chem. B, 2009, 113, 531.
2. Guo, L., Chowdhury. P., Glasscock, J. M., Gai, F. Denaturant-induced expansion and compaction of a multi-domain protein: IgG. J. Mol. Biol. 2008, 384, 1029.
3. Mukherjee, S., Chowdhury, P., Bunagan, M. R. and Gai, F. Folding kinetics of a naturally occurring helical peptide: implication of the folding speed limit of helical proteins. J. Phys. Chem. B, 2008, 112, 9146.
4. Chowdhury, P., Wang, W., Lavender, S., Bunagan, M. R., Klemke, J. W., Tang, J., Saven, J. G., Cooperman, B. S. and Gai, F. Fluorescence correlation spectroscopic study of serpin depolymerization by computationally designed peptides. J. Mol. Biol. 2007, 369, 462.
Group Members

Ashima Malik (PhD)
Ravikant Srivastava (PhD)
Jayanta Kundu (PhD)
Priyanka Singh (MTech)
Sandeep Karmakar (MSc)
Sanjib Kundu (MSc)
Prithwish SinhaRoy (MSc)
Information

For email suffix @chemistry.iitd.ac.in

Department of Chemistry, Indian Institute of Technology Delhi