Pramit K Chowdhury

Pramit Chowdhury

Associate Professor

Born: Kolkata, West Bengal
Ph. D. (Prof. J. W. Petrich), Iowa State University, USA, 1999-2004
Post Doctoral Fellow (Dr. Feng Gai), University of Pennsylvania,USA, (Sep-2004 to January-2009)
Joined Indian Institute of Technology Delhi in January 2009.

Group Webpage

Research Interests

Protein folding and aggregation.

Our main focus is to use single molecule confocal microscopy techniques like fluorescence resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS) to monitor protein dynamics. In particular, we want to lay special emphasis on how macromolecular crowding and confinement influence the folding and aggregation of proteins.

research pic
(a) Confinement (b) Macromolecular crowding. The unfolded protein is shown in red while the blue sphere represents its native form. The dark spheres in (b) are the inert macromolecular crowders. (Figure adapted from Zhou, Annual Reviews of Biophysics, 2008)

Selected Publications

  1. Mukherjee, S., Chowdhury P. and Gai, F. Effect of dehydration on the aggregation kinetics of two amyloid peptides. J. Phys. Chem. B, 2009, 113, 531.
  2. Guo, L., Chowdhury. P., Glasscock, J. M., Gai, F. Denaturant-induced expansion and compaction of a multi-domain protein: IgG. J. Mol. Biol. 2008, 384, 1029.
  3. Mukherjee, S., Chowdhury, P., Bunagan, M. R. and Gai, F. Folding kinetics of a naturally occurring helical peptide: implication of the folding speed limit of helical proteins. J. Phys. Chem. B, 2008, 112, 9146.
  4. Chowdhury, P., Wang, W., Lavender, S., Bunagan, M. R., Klemke, J. W., Tang, J., Saven, J. G., Cooperman, B. S. and Gai, F. Fluorescence correlation spectroscopic study of serpin depolymerization by computationally designed peptides. J. Mol. Biol. 2007, 369, 462.

      Group Members

  • Ashima Malik (Ph.D.)
  • Ravikant Srivastava (Ph.D.)
  • Jayanta Kundu (Ph.D.)
  • Priyanka Singh (M.Tech.)